Syngenta at Mount Jethro International Research Centre in the UK currently has an LC mass spectrometer that can only match one of ESI or APCI ion sources. When switching between ESI and APCI ion sources, it is necessary to cool the ion source, manually remove and install a new ion source, and then heat the new ion source to operating temperature, resulting in lower analysis flux when both ESI and APCI ion sources need to be used simultaneously. Therefore, in order to facilitate the use of QSight 220 triple quadrupole LC/MS/MS and achieve high flux, most analyses only use ESI ion sources. When PerkinElmer produces QSight equipped with both ESI and APCI ion sources ® The effectiveness of using 220 for routine screening of analytes in Syngenta was tested, and the results are presented here.

This study indicates that QSight 220 has a dual independent ion source capable of measuring simultaneously in ESI and APCI modes, covering different categories of compounds and having a low quantification limit even in complex matrices. QSight 220 can easily switch between ESI ion source and APCI ion source, allowing users to quickly check the response of different compounds to ESI ion source and APCI ion source, and determine which ion source to usesuitableMeasure low sensitivity analytes. The dual ion source function equipped with a switching valve can shorten the time required to switch from ESI to APCI from approximately one hour to almost no time, without the need for manual intervention.