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About Us
Tianjin Xun'er Technology Co., Ltd
Date: 2025-03-13Read: 6
In the vast field of exploring life sciences and biotechnology, biological fermentation, as an ancient and powerful technology, has always held a pivotal position.
Biological fermentation refers to the process of using microorganisms, animals, and plants to convert raw materials into products needed by humans through specific metabolic pathways under suitable conditions. In the pharmaceutical industry, biological fermentation technology is widely used in the production of biological products such as antibiotics and vaccines.
Modern pharmaceutical companies have increasingly high requirements for instrumentation and self-control, and the level of instrumentation and self-control largely reflects a pharmaceutical company's technological level. The fermentation process is also the same, especially in terms of flow control,Accurate control of various fluids entering and exiting the bioreactor is crucial for the production quality of biologics, such as reactor feeding/batching, fermentation kettle batching, reactor feeding, multi-media mixing and transportation, high-precision batching, and other processes.
Application of flow meters in biological fermentation process
Reactor inlet/ingredients：
A bioreactor is the core equipment in the biological fermentation process, used to control the growth environment and metabolic conditions of bacterial cells. It is necessary to accurately control the flow rate of nutrient solution in the reactor through a flow meter to ensure that the bacterial cells grow under optimal conditions, thereby improving the quality and yield of the product.
Gas distribution system：
In the process of biological fermentation, it is necessary to accurately adjust the proportions of various gases according to different fermentation stages and bacterial requirements. Realize precise ratio and flow control of multiple gases to ensure the stability and reliability of the fermentation process.
Fermentation kettle ingredients：
A fermentation tank is a container used for cultivating bacterial cells during the biological fermentation process. Accurate control of the flow rate of the culture medium is required through flow meters to maintain a suitable environment inside the tank and promote the growth and metabolism of bacterial cells.
Xun'er on-site application case
A domestic biopharmaceutical company's antibiotic production line fermentation process requires the use of glucose aqueous solution, nitrogen source aqueous solution, culture medium aqueous solution, and glycerol aqueous solution as raw materials for fermentation reactions. The temperature, pressure, concentration, flow rate, and flow rate during the process need to be monitored simultaneously pH、 Liquid level, etc. The commonly used flow range for various solutions is 30L/h-3m3/h, with a density of 1kg/m3 and a pipeline diameter of DN15-DN20.
In addition, because the fermentation of bioengineering is often accompanied by the problem of foam, quantitative addition of fermentation defoamer is also required in the reactor.
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In pharmaceutical reaction vessels, various fluid raw materials can be accurately measured to ensure the accuracy of dosage;
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Continuous flow real-time control;
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The instrument performance is stable and meets the requirements of hygiene and cleanliness;
In communication with customers, it was learned that fermentation itself is a biological process, and the materials used in the fermentation process are also good culture media that are conducive to microbial growth. Therefore, it is particularly important to ensure that the production process is not contaminated by other microorganisms. The customer's fermentation tank and pipeline adopt SIP (online steam sterilization) method,For pipeline entryPerform cleaning and sterilizationTo ensure proper sterilization before vaccination.
Customer feedback: The instrument selection of Xun'er this time is in line with the pipeline design. Since the official use of the production line, it has ensured precise measurement and efficient control of the injected raw materials. Helping enterprises improve the stability and reliability of biological fermentation processes, and enhancing product quality and yield.At the same time, the design of Xun'er flow meters hasEasy to maintain, compact structure, simple operation, convenient for enterprises to carry out daily maintenance and upkeep, reducing usage costs.
Recommended on-site application products
Product Features:
Various liquid receiving materials such as 304/316L are available for users to choose from, suitable for high cleanliness occasions such as food and medicine;
Adopting a dual micro bend flow tube design, high accuracy can generally reach 0.10 or 0.15 levels;
It can directly measure the mass flow rate of fluids in closed pipelines and the working density of media, and can be used as a high-precision online density meter;
■ Integrated or split installation structure, saving installation costs;
Wide measurement range, covering a flow rate range of 0.035t/h to 40.5t/h;
Multiple standard flange connection methods are available for users to choose from;
High stability without the need for frequent disassembly and calibration;
No rectification or filtering components are required, and there are no special installation requirements such as straight pipe sections;
■ Non blocking components and larger flow paths reduce pressure loss, energy consumption, and waste;
Product Features:
Suitable for routine sanitary applications;
High accuracy level, up to 0.2 level;
Good measurement repeatability, with a maximum repeatability of 0.03%;
The caliber covers a wide range, DN4~DN2000;
Almost no pressure loss, no flow blocking components;
Corrosion resistant, capable of testing the vast majority of corrosive conductive liquids;
Multiple signal outputs, equivalent, frequency, current, and RS485 communication interfaceAnd there are buses such as HART, PROFIBUS, FF, as well as GPRS, NB, etc4G and other wireless communication methods are optional.
Product Features:
■ Simple assembly structure and easy replacement;
■ Spring type temperature sensing element with good seismic performance;
Large measurement range and high measurement accuracy;
High mechanical strength and good pressure resistance;
Short response time.